General name: florfenicol powder

Trade name: Kangfuxin

English Name: florfenicol powder

Hanyu Pinyin: fubenikao Fen

Florfenicol

This product is white or off white powder.

Pharmacodynamics: florfenicol belongs to amide alcohol broad-spectrum antibiotics and bacteriostatic agents. It plays a role by inhibiting the synthesis of bacterial proteins by binding with ribosomal 50S subunit. It has strong antibacterial activity against a variety of gram-positive and Gram-negative bacteria. Pasteurella haemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae were highly sensitive to florfenicol. The antibacterial activity of florfenicol against many microorganisms in vitro is similar to or stronger than that of thiamphenicol. Some bacteria resistant to amidol due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be sensitive to florfenicol. It is mainly used for bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, such as respiratory diseases of cattle and pigs caused by Pasteurella haemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae. Typhoid and paratyphoid fever caused by Salmonella, chicken cholera, chicken dysentery, colibacillosis, etc; Bacterial septicemia, enteritis and erythroderma of fish caused by Pasteurella, Vibrio, Staphylococcus aureus, Aeromonas hydrophila and enteritis bacteria.

Pharmacokinetics: florfenicol is absorbed rapidly after oral administration. The therapeutic concentration can be reached in the blood after about 1 hour, and the peak blood concentration can be reached in 1 ~ 3 hours. The bioavailability is more than 80%. Florfenicol is widely distributed in animals and can penetrate the blood-brain barrier. It is mainly discharged from urine in its original form, and a small amount is discharged with feces.

(1) Macrolides and lincolamines have the same action target as this product. They both bind to the 50S subunit of bacterial ribosome, and can produce mutual antagonism when combined.

(2) It may antagonize the bactericidal activity of penicillins or aminoglycosides, but it has not been proved in animals.

Amide alcohol antibiotics. For Pasteurella and Escherichia coli infection.

Based on this product. Oral administration: 0.2 ~ 0.3g for pigs and chickens per 1kg body weight, twice a day for 3 ~ 5 days; Fish 0.1 ~ 0.15g, once a day, for 3 ~ 5 days.

(1) This product has certain immunosuppressive effect when it is higher than the recommended dose.

(1) Chickens that lay eggs for human consumption shall not be used during the laying period.

(2) Use with caution when breeding chickens. It has embryotoxicity. It should be used with caution for livestock during pregnancy and lactation.

(3) Animals with severe immune deficiency during vaccination or immune function are prohibited.

(4) Animals with renal insufficiency need to appropriately reduce or prolong the interval of administration.

Pig 20 days, chicken 5 days, fish 375 degrees a day.

10%

Sealed and stored in a dry place.