Common name: compound sulfaclodazine sodium powder

English Name: Compound Sul fachlorpyridazine sodium powder

Hanyu Pinyin: Fufang Huang’ an Lidaqinna Fen

Sulfachlordazine sodium, trimethoprim

This product is light yellow powder

This product has a strong inhibitory effect on most Gram-positive and Gram-negative bacteria. Under the condition of the activation of the bacteria in the synthesis of tetrahydrofluoric acid, tetrahydrofluoric acid and thymidine can only play an important role in the synthesis of aminophylline. Sulfonamides are similar to p-aminobenzoic acid in structure. They can compete with p-aminobenzoic acid for dihydrofolate synthase in bacteria, hinder the synthesis of dihydrofolate, and finally affect the synthesis of nucleic acid and inhibit the growth and reproduction of bacteria. The effect of sulfonamides can be antagonized by drugs that can metabolize into p-aminobenzoic acid, such as procaine and Decaine. In addition, pus and tissue decomposition products can also provide essential substances for bacterial growth and have antagonistic effects with sulfonamides. Trimethoprim is an antibacterial synergist, which can inhibit the activity of dihydrofolate reductase. The combination of the two can produce synergistic effect and enhance the antibacterial effect.

(1) Some drugs containing p-aminobenzoyl, such as procaine and tetracaine, can produce p-aminobenzoic acid in the body. Yeast tablets contain p-aminobenzoic acid required for bacterial metabolism, which can reduce the effect of this drug, so it is not suitable for use

(2) When used with diuretics such as thiazide or furosemide, it can aggravate nephrotoxicity.

(3) Sulfonamides can usually replace the following drugs with high protein binding rate, such as methotrexate, butazone, thiazide diuretics, salicylate, probenecid and letonin. Although the clinical significance of these interactions is not completely clear, the enhancement effect of the replaced drugs must be monitored.

(4) The combination of antacids and sulfonamides can reduce their bioavailability.

Sulfonamides. It is used for Escherichia coli and Pasteurella infection of livestock and poultry.

Based on this product.

Oral administration: daily dose, 32mg for pigs and chickens per 1kg body weight; Pigs for 5 ~ 10 days: chickens for 3 ~ 6 days.

The main manifestations are acute reactions such as allergic reactions, and chronic reactions include granulocytopenia, thrombocytopenia, liver damage, kidney damage and central nervous toxicity. It is easy to deposit in urine, especially in high-dose and long-term medication.

(1) Chickens that lay eggs for human consumption shall not be used during the laying period.

(2) It shall not be used as feed additive for a long time.

(3) It is easy to precipitate crystals in the urinary tract, and the affected animals should be given a lot of drinking water. The same amount of sodium bicarbonate should be given at the same time for high-dose and long-term application.

(4) When the renal function is damaged, the excretion is slow and should be used with caution.

(5) It can cause intestinal flora imbalance. Long term medication can reduce the synthesis and absorption of B vitamins and vitamin K. It is appropriate to supplement corresponding vitamins.

(6) It cannot be used in sick animals with a history of allergy to sulfonamides.

Pig 4 days, chicken 2 days.

1000g: sodium sulfachlordazine 625g + trimethoprim 125g

遮光，密闭保存。