Common name: flunixin meglumine granules

Trade name: Pujia

English Name: fluixin meglumine granules

Pinyin: funixin Pujia 'an Keli

Flunixin meglumine

This product is off white or light yellow particles.

Pharmacodynamics: flunixin meglumine is a powerful cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory and anti rheumatic effects. The analgesic effect is caused by blocking the transmission of pain impulse by inhibiting the synthesis of peripheral exemplar adenosine or its pain sensitizing substance or their joint action. The anti-inflammatory effect of peripheral tissue may be caused by inhibiting cyclooxygenase, reducing the formation of prostaglandin precursors, and inhibiting local inflammatory response caused by other mediators. Flunixin meglumine does not affect gastrointestinal peristalsis in horses, but may improve hemodynamics in animals with septic shock. Pharmacokinetics: after a single intramuscular injection in pigs (2.2mg/kg body weight), the elimination half-life of plasma is 3 ~ 4 hours, the peak concentration is 2.94 UG / ml, and the peak time is 0.4 hours. The drug can still be detected in the blood 18 hours after administration. The apparent distribution volume was 2.0l/kg, and the bioavailability of single neck injection was 87%.

(1) When used together with other non steroidal anti-inflammatory drugs, it will aggravate the toxic and side effects on the gastrointestinal tract, such as ulcer, bleeding and so on.

(2) Due to the high binding rate of plasma protein, when combined with other drugs, flunixin meglumine may replace other drugs combined with plasma protein or be replaced by other drugs, resulting in enhanced effect and even toxicity of the replaced drugs.

Antipyretic and analgesic anti-inflammatory drugs. It is used for febrile and inflammatory diseases, muscle pain and soft tissue pain of livestock and small animals.

Based on this product. Oral administration: once for every 1kg of body weight, 40mg for dogs and cats, 1-2 times a day for no more than 5 days.

Long term high-dose use of this product may cause gastric ulcer and renal function injury in animals.

(1) Animals with peptic ulcer should be used with caution.

(2) Do not use with other non steroidal anti-inflammatory drugs at the same time.

There is no need to develop.

C₁₄H₁₁F₃N₂O₂5%

Keep in a dark and airtight place.